Clinical Conditions

Prostate cancer grows in response to testosterone. Testosterone is produced in the testicles and the adrenal gland. Testosterone production can be stopped in two ways. The testicles can be removed with a procedure called an orchiectomy. Similarly, testosterone production can be stopped with medications such as leuprolide or goserelin acetate that suppress the pituitary gland and thus decrease production in the testes. This is know as androgen deprivation therapy (ADT). ADT is not a curative therapy, but is reserved for metastatic disease or for patients that will not medically tolerate surgery or radiation. ADT can relieve symptoms from painful bone metastases and slow the overall growth rate of prostate cancer cells. Other medications used for ADT are listed below:

  • Aminoglutethamide
  • Casodex (biclutamide)
  • Cyproterone
  • DES (diethylstilbesterol)
  • Estrogen (megestrol acetate)
  • Eulexin (flutamide)
  • Lutenizing Hormone Releasing Hormone (LHRH,leuprolide/ Zoladex-goserelin)
  • Nizoral (ketoconazole)