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Dr. Darius A. Paduch is an assistant professor of urology and reproductive medicine at Weill Cornell Medical College, associate research director of the Fellowship program in male reproductive medicine and microsurgery, associate director of genetics laboratory, and a staff scientist at the Population Council. He received his medical degree from Medical Academy of Lodz in Poland, and Ph.D. in molecular microbiology from Polish Mother Memorial Research Institute. Prior to moving to USA he worked at the Department of Pediatric Surgery and Urology in Medical Academy of Lodz, where he was a co-funder of the first childhood and adolescent andrology clinic in Poland. He finished residency in urology at Oregon Health Science University in Portland, Oregon, followed by two-year postdoctoral fellowship in male infertility, Andrology and molecular endocrinology at Weill Cornell Medical College and at Population Council in New York. Since 2005 he joined the department of urology and reproductive medicine at WCMC.

He has busy clinical practice devoted exclusively to evaluation and treatment of male infertility and sexual dysfunction in men. In his clinical work and clinical research he focuses on the pathophysiology of Klinefelter syndrome and molecular mechanism of testicular failure. He made significant progress in our understanding of physiology of ejaculatory and orgasmic dysfunction and designed new testing of sexual dysfunction. He is nationally recognized as one of top experts on Klinefelter syndrome in adolescents, orgasmic dysfunction in men, and male reproductive endocrinology.

His laboratory focuses on the genetics of male infertility, sperm chromatin structure, and estradiol signaling in testis. His laboratory was the first to uncover the mechanism of estradiol driven impairment in steroidogenesis in human testis.